Estrogen, Cancer and Immune Dysfunction

Considerable evidence suggests that estrogen dominance promotes immunological overactivity/imbalance.  This overabundance of estrogen may cause autoimmune diseases i.e., over activity of normal immune function.  This imbalance is related to certain diseases such as rheumatoid arthritis and systemic lupus erythematosus (SLE).  Androgens (testosterone, DHEA) and progesterone are natural immune suppressors which have a balancing effect on the immune system.

Indole 3 carbinol (I3C) is a nutritional compound present in cruciferous vegetables (broccoli and cauliflower) that can shift estrogen metabolism towards less estrogenic metabolites.

It has been suggested that I3C, through decreasing a woman’s and man’s estrogen levels, might also reduce the severity of estrogen dependent diseases such as SLE, prostate cancer and other estrogen dependent cancers. Click here to read more!

Ref: Indole 3 Carbinol in Women with SLE: effect of estrogen metabolism and disease activity. Lupus. 2001; 10: 779-783.

Submitted by Dr. Jeffrey J. Hunt Naturopathic Physician

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